Urinary Tract Infection
Urinary tract infection (UTI) occurs when pathogenic bacteria enter the urethra and cause infection and inflammation. The urethra alone may be affected (urethritis), but more commonly the infection reaches the bladder (cystitis). The kidneys may also be involved (pyelonephritis), sometimes leading to complicated UTI, stone formation, and/or sepsis. The remainder of this chapter focuses primarily on acute, uncomplicated cystitis.
UTIs are common in all age groups. The bacterial pathogens originate from fecal flora. Escherichia coli ( E coli) are the most common (≈ 85%). Staphylococcus saprophyticus, Klebsiella, Proteus, and Enterococcus may also cause infection.
In most cases, these pathogenic bacteria appear to be foodborne. Using genetic matching techniques, researchers from several countries have found that pathogenic E coli in women with urinary tract infections often originate in retail chicken products. , The poultry counter appears to act as a reservoir for pathogenic E coli, a problem that may be aggravated by drug resistance related to the use of antibiotics on farms.
Cystitis is generally a clinical diagnosis, and radiologic investigation is not usually required except in certain cases involving children (e.g., when febrile, when known risk factors are present, or in males). The usual symptoms of cystitis are dysuria, urinary frequency, and urinary urgency. However, urinary tract infections are frequently asymptomatic, particularly in the elderly. Pain in the suprapubic region may be reported, and hematuria and cloudy urine may occur as well. Patients with pyelonephritis typically present with fever spikes, nausea/vomiting, and costovertebral pain.
In elderly persons, confusion and other mental status changes may be the only signs of a urinary tract infection. Among children, symptoms typically include irritability, changes in eating habits, incontinence, and diarrhea. Vomiting or sensation of incomplete voiding may be the only symptom in young girls.
Gender. Females have UTIs more frequently, compared with males, due to a shorter urethra that is in closer proximity to the perineum. More than 50% of women will have a urinary tract infection during their lifetime, with 20% of these women experiencing 2 or more infections. In men, UTIs are rare (less than 0.1%), except in cases of anatomic abnormalities.
Sexual intercourse. Recent intercourse raises the risk of UTI in women. Risk is increased with a new sexual partner, as well as the use of spermicide.
Urinary tract obstruction. Prostatic enlargement (benign prostatic hyperplasia or cancer) or inflammation, nephrolithiasis, and other obstructions raise UTI risk.
Anatomic abnormalities. These may include ureterovesical reflux.
Diabetes mellitus. Hyperglycemia and neurogenic bladder predispose to infection.
Menopause. Atrophic urogenital changes after menopause increase risk.
The diagnosis of acute cystitis can usually be made by history. Acute onset of dysuria, urinary frequency, and absence of vaginal symptoms usually warrant empiric treatment. A urine dip or urinalysis (of a sample collected midstream) is an inexpensive way to help confirm suspicion, where leukocytes, red blood cells, and/or nitrites may be noted. False-positive and false-negative tests are frequent.
Urine culture is not indicated in an uncomplicated bladder infection, unless resistance to standard antibiotic therapies is likely. In complicated and recurrent infections, a urine culture and sensitivity should be done. Standard urine cultures may be negative in urethritis caused by chlamydia. Blood cultures should be performed if pyelonephritis is suspected; bacteremia is present in about a third of cases.
Persons with recurrent or refractory infections may need diagnostic testing for anatomic abnormalities. This may require ultrasound, a spiral CT scan for kidney stones, intravenous pyelogram, cystogram, and cystoscopy.
Cigarette smokers with UTI, hematuria, and irritation during voiding should be evaluated for malignancy (transitional cell carcinoma) with CT intravenous pyelogram, cystoscopy, and urine cytology.
Uncomplicated cases of urinary tract infection usually require a 3- to 7-day course of antibiotic therapy. A longer course of antibiotics may be necessary for patients with a history of UTI, immunocompromise, diabetes, or prolonged symptoms. For chronic UTI, treatment lasting 6 months or more, along with prophylactic antibiotics, may be needed.
Empiric Treatment for Uncomplicated UTI
Nitrofurantoin-macrocrystals, used twice a day for 5 days, are an effective treatment, and bacterial resistance is rare.
Trimethoprim/sulfamethoxazole (TMP/SMX), used twice a day for 3 days, is appropriate for empirical therapy if local resistance rates are < 20%, but prevalence of resistant bacteria is increasing.
Fosfomycin trometamol is an option but may be less effective than other therapies.
Fluoroquinolones are less appropriate for empiric therapy because of their broad spectrum of bacterial coverage. In TMP/SMX-resistant bacteria, resistance to fluoroquinolones occurs more frequently than to nitrofurantoin.
Treatment based on culture and sensitivity will likely include one of the above drug classes. Cost-effective therapy with the narrowest-spectrum agent should be used.
Other possible antibiotics include sulfonamides, trimethoprim, and cephalosporins.
Fluoroquinolones (except for moxifloxacin) are first-line empiric agents. Nitrofurantoin and TMP/SMX are not appropriate empiric therapies due to high resistance rates.
Treatment usually is needed for at least 5-10 days and may require hospitalization and pathogen-focused drugs.
Uncomplicated pyelonephritis can be treated with TMP/SMX for 14 days, if resistance is not likely. Ciprofloxacin for 7 days is also a good option for outpatients in areas where local resistance is known to be < 10%.
Complicated pyelonephritis will require hospitalization and pathogen-focused IV antibiotics. These include ampicillin and gentamicin, TMP/SMX, fluoroquinolones, and third-generation cephalosporins.
Various anti-microbial prophylactic regimens (continuous, intermittent, and post-coital), may help recurrent UTIs. Voiding immediately after intercourse has not been proven helpful in reducing the risk of recurrent UTIs.
Phenazopyridine (Pyridium) is an analgesic that can be used for dysuria. It may turn the urine orange or red, and give a false-positive nitrite test because of the discolored urine.
The role of diet in the prevention and treatment of urinary tract infection remains unsettled. As noted above, pathogenic bacteria often originate in chicken products and pass through the intestinal tract before arriving at the urethra. It remains to be established whether avoiding contact with chicken could reduce UTI incidence.
Some nutritional strategies with anecdotal support (vitamin C, high intake of fluids) have not demonstrated clinical effectiveness. Others, such as cranberry juice, have proven effective in clinical trials. Still others, such as probiotic treatment and high-fiber diets, await further evaluation. In epidemiologic or clinical studies, the following factors are associated with reduced risk:
Breastfeeding. Secretory immunoglobulin A (sIgA) in breast milk prevents the translocation of intestinal bacteria across the gut mucosa by blocking interactions between bacteria and the epithelial lining of the gut. Breastfeeding also alters the colonization of the gut, achieving a reduced presence of the P-fimbriated type of E coli associated with higher risk for UTI. Non-breastfed babies have been shown to have, on average, twice the risk for urinary tract infection, compared with infants who were breastfed for at least 7 months. The benefit of breastfeeding is particularly large in girls. It may reduce the risk of UTI even after weaning.
Flavonoid-containing juices. Certain classes of flavonoids (e.g., epicatechin) block adhesion of E coli fimbria to uroepithelial cells. They may also prevent UTI by other mechanisms, such as the down-regulation of genes in E coli responsible for fimbrial expression. Epidemiologic and clinical studies show that women who consume cranberry or cranberry-lingonberry juices have a 20% lower risk for UTI compared with those not drinking juice, a finding comparable to that of continuous low-dose antimicrobial prophylaxis., The optimal dosage has not yet been standardized nor is it clear which populations are most likely to benefit. , Further research is warranted.
Lactobacilli. Limited evidence suggests that women who consume probiotic lactobacilli have a significantly (80% lower) decreased risk for UTI. Further research is needed to establish the most effective strains. Lactobacilli can be purchased over the counter in many health food stores and pharmacies.
High-fiber diets. Constipation is a risk factor for UTI and recurrent UTI, although the reasons are unclear. Clinical trials have not yet established the usefulness of dietary fiber for UTI prevention, but increasing high-fiber foods in persons with low-fiber diets is a potentially beneficial strategy.
Breastfeeding for at least 6 months, and longer if possible, is recommended.
For adults wishing to use flavonoid-containing juices as a preventive measure, cranberry juice consumed 3 times daily with meals would be appropriate.
What to Tell the Family
Urinary tract infection is often a combined result of a decreased ability to prevent opportunistic infection and the presence of a common ( E coli) bacterial strain that travels from the gastrointestinal tract into the urethral opening. Careful personal hygiene is essential for prevention. Infections are generally treated by antibiotics to prevent kidney damage. Timed voiding may help (i.e., emptying bladder every 3-4 hours), along with drinking plenty of water (~ 80 oz daily in adults).
- Bergeron CR et al: Chicken as reservoir for extraintestinal pathogenic Escherichia coli in humans, Canada. Emerging Infect Dis 18:415, 2012 [PMID:22377351]
- Manges AR: Escherichia coli and urinary tract infections: the role of poultry-meat. Clin Microbiol Infect 22:122, 2016 [PMID:26679924]
- Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med . 2002;113 Suppl 1A:5S-13S.
- Zalmanovici Trestioreanu A et al: Antibiotics for asymptomatic bacteriuria. Cochrane Database Syst Rev 4:, 2015 [PMID:25851268]
- Nicolle LE et al: Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 40:643, 2005 [PMID:15714408]
- Gupta K et al: International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103, 2011 [PMID:21292654]
- Karlowsky JA et al: Susceptibility of antimicrobial-resistant urinary Escherichia coli isolates to fluoroquinolones and nitrofurantoin. Clin Infect Dis 36:183, 2003 [PMID:12522750]
- Kontiokari T, Nuutinen M, Uhari M: Dietary factors affecting susceptibility to urinary tract infection. Pediatr Nephrol 19:378, 2004 [PMID:14986090]
- Wold AE, Adlerberth I: Breast feeding and the intestinal microflora of the infant--implications for protection against infectious diseases. Adv Exp Med Biol 478:77, 2000 [PMID:11065062]
- Avorn J et al: Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 271:751, 1994 [PMID:8093138]
- Blumberg JB et al: Cranberries and their bioactive constituents in human health. Adv Nutr 4:618, 2013 [PMID:24228191]
- Jepson RG, Williams G, Craig JC: Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 10:, 2012 [PMID:23076891]
- Liska DJ, Kern HJ, Maki KC: Cranberries and Urinary Tract Infections: How Can the Same Evidence Lead to Conflicting Advice? Adv Nutr 7:498, 2016 [PMID:27184277]
- Kontiokari T et al: Dietary factors protecting women from urinary tract infection. Am J Clin Nutr 77:600, 2003 [PMID:12600849]
- Schwenger EM, Tejani AM, Loewen PS: Probiotics for preventing urinary tract infections in adults and children. Cochrane Database Syst Rev Dec 23 [PMID:26695595]
- Hari P, Mantan M, Bagga A: Management of urinary tract infections. Indian J Pediatr 70:235, 2003 [PMID:12785296]
- Issenman RM, Filmer RB, Gorski PA: A review of bowel and bladder control development in children: how gastrointestinal and urologic conditions relate to problems in toilet training. Pediatrics 103:1346, 1999 [PMID:10353952]